Substituted hexahydrobenzodipyrans as 5-HT2A/2C receptor probes.
作者信息
Whiteside Michael S, Kurrasch-Orbaugh Deborah, Marona-Lewicka Danuta, Nichols David E, Monte Aaron
机构信息
Department of Chemistry, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
出版信息
Bioorg Med Chem. 2002 Oct;10(10):3301-6. doi: 10.1016/s0968-0896(02)00209-2.
Abstract
A pair of substituted hexahydrobenzodipyrans was designed as molecular probes for determining the steric restrictions of the agonist binding site of serotonin 5-HT2A and 5-HT2C receptors. The rationale for the design of these receptor ligands, their chemical synthesis, rat behavioral pharmacology in the two-lever drug discrimination assay using LSD-trained rats, affinity for cloned rat 5-HT2A and 5-HT2C receptors and agonist functional activities are reported.
摘要
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