“shmoos”、“筏”和尾足——细胞极性的多个方面。

Shmoos, rafts, and uropods- the many facets of cell polarity.

作者信息

Dustin Michael L

机构信息

Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

出版信息

Cell. 2002 Jul 12;110(1):13-8. doi: 10.1016/s0092-8674(02)00820-6.

DOI:10.1016/s0092-8674(02)00820-6

PMID:12150993

Abstract

The recent Juan March Foundation meeting on "Regulation and functional insights in cellular polarity" focused on cellular polarity in yeasts, Dictyostelium, epithelial cells, fibroblasts, and immune cells. The molecular systems covered included membrane rafts, actin and tubulin cytoskeleton, polarized transcription, signaling, and cell-cell adhesion. Across these diverse biological and molecular systems, important general concepts emerged, including new ideas for establishing and maintaining polarity that are likely to be applicable across models and experimental systems.

摘要

最近胡安·马尔基金会关于“细胞极性的调控与功能洞察”的会议聚焦于酵母、盘基网柄菌、上皮细胞、成纤维细胞和免疫细胞中的细胞极性。所涵盖的分子系统包括膜筏、肌动蛋白和微管蛋白细胞骨架、极化转录、信号传导以及细胞间黏附。在这些多样的生物学和分子系统中，出现了一些重要的通用概念，包括关于建立和维持极性的新观点，这些观点可能适用于各种模型和实验系统。