高效液相色谱分析过程中4,5-环氧吗啡喃降解情况的研究。
Investigation of 4,5-epoxymorphinan degradation during analysis by HPLC.
作者信息
Quarry Mary Ann, Sebastian Dolores S, Diana Frank
机构信息
DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880, USA.
出版信息
J Pharm Biomed Anal. 2002 Aug 22;30(1):99-104. doi: 10.1016/s0731-7085(02)00166-8.
Abstract
Compounds of the 4,5-epoxymorphinan series have been shown to degrade in solution to the corresponding 2,2'-dimers when stored in amber glass HPLC vials. A colorant in the glass has been shown to catalyze the degradation. Although amber glass is routinely used to protect solutions from light degradation, it should not be used without evaluating its effect on sample stability.
摘要
4,5-环氧吗啡喃系列化合物已被证明，当储存在琥珀色玻璃高效液相色谱小瓶中时，会在溶液中降解为相应的2,2'-二聚体。玻璃中的一种着色剂已被证明可催化这种降解。虽然琥珀色玻璃通常用于保护溶液免受光降解，但在未评估其对样品稳定性的影响之前，不应使用。
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