Dallinga Jan W, Moonen Edwin J C, Dumoulin John C M, Evers Johannes L H, Geraedts Joep P M, Kleinjans Jos C S
Department of Health Risk Analysis and Toxicology, Faculty of Health Sciences, Maastricht University, P.O.Box 616, 6200 MD, Maastricht, The Netherlands.
Hum Reprod. 2002 Aug;17(8):1973-9. doi: 10.1093/humrep/17.8.1973.
Various studies have been performed in which potential effects of xenoestrogens on fertility or sperm parameters were investigated by comparing groups of subjects exposed to different levels of these chemicals.
In our study we used an alternative approach, as we selected one group of men with very poor semen quality and another group with normal semen quality and determined the blood organochlorine contents in order to determine whether a difference in these levels could be established. Organochlorine compounds, including polychlorinated biphenyls (PCB) and PCB metabolites, were detected using gas chromatography. The concentrations were compared between both groups, and related to semen parameters.
A comparison of both groups did not reveal significant differences in organochlorine levels. Linear relationships were found when PCB and metabolite concentrations were related to the age of the volunteers. Focusing on the subgroup of men with normal semen quality showed that sperm count and sperm progressive motility were inversely related to the concentrations of PCB metabolites within this group.
The finding of a significantly decreased sperm count in relation to an elevated PCB metabolite level within the subgroup of men with normal semen quality is important. This is the first time that a correlation between exposure to environmental pollutants with endocrine-disrupting capacity and human sperm quality has been observed.
已经开展了各种研究，通过比较接触不同水平这些化学物质的受试者组，来调查外源性雌激素对生育能力或精子参数的潜在影响。
在我们的研究中，我们采用了另一种方法，即选择一组精液质量非常差的男性和另一组精液质量正常的男性，测定血液中有机氯含量，以确定是否能发现这些水平的差异。使用气相色谱法检测有机氯化合物，包括多氯联苯（PCB）及其代谢产物。比较两组之间的浓度，并将其与精液参数相关联。
两组比较未发现有机氯水平有显著差异。当PCB及其代谢产物浓度与志愿者年龄相关时，发现存在线性关系。关注精液质量正常的男性亚组显示，该组内精子数量和精子前向运动能力与PCB代谢产物浓度呈负相关。
在精液质量正常的男性亚组中，发现精子数量显著减少与PCB代谢产物水平升高有关，这一点很重要。这是首次观察到接触具有内分泌干扰能力的环境污染物与人类精子质量之间的相关性。
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