Wang Aolin, Padula Amy, Sirota Marina, Woodruff Tracey J
Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California; Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, California.
Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California.
Fertil Steril. 2016 Sep 15;106(4):905-29. doi: 10.1016/j.fertnstert.2016.07.1076. Epub 2016 Aug 9.
Chemical exposures during pregnancy can have a profound and life-long impact on human health. Because of the omnipresence of chemicals in our daily life, there is continuous contact with chemicals in food, water, air, and consumer products. Consequently, human biomonitoring studies show that pregnant women around the globe are exposed to a variety of chemicals. In this review we provide a summary of current data on maternal and fetal exposure, as well as health consequences from these exposures. We review several chemical classes, including polychlorinated biphenyls, perfluoroalkyl substances, polybrominated diphenyl ethers, phenols, phthalates, pesticides, and metals. Additionally, we discuss environmental disparities and vulnerable populations, and future research directions. We conclude by providing some recommendations for prevention of chemical exposure and its adverse reproductive health consequences.
孕期接触化学物质会对人类健康产生深远且终身的影响。由于化学物质在我们日常生活中无处不在，人们持续接触食物、水、空气和消费品中的化学物质。因此，人体生物监测研究表明，全球孕妇都接触到多种化学物质。在本综述中，我们总结了有关母体和胎儿接触化学物质的现有数据，以及这些接触所带来的健康后果。我们回顾了几类化学物质，包括多氯联苯、全氟烷基物质、多溴二苯醚、酚类、邻苯二甲酸盐、农药和金属。此外，我们还讨论了环境差异和弱势群体，以及未来的研究方向。最后，我们针对预防化学物质接触及其对生殖健康的不良后果提出了一些建议。
