Mignon F, Vasmant D, Richet G, Wang A, Morel-Maroger L, Brouet J C
Ann Med Interne (Paris). 1979;130(11):513-6.
The authors describe a case which demonstrates that nephrotic syndromes occuring during the course of a myeloma are not always of the amyloid type. They emphasize the possibility of a dysglobulinemia being involved in a glomerular nephropathy syndrome, especially when there are histological lesions of a glomerulosclerosis. The published literature is reviewed and the possible pathogenesis of these nephropathies briefly discussed: either protein deposits, the nature of which has not been fully determined, or mesangial modifications induced by the filtered light chains.
作者描述了一个病例，该病例表明骨髓瘤病程中出现的肾病综合征并不总是淀粉样变类型。他们强调了球蛋白异常血症参与肾小球肾病综合征的可能性，尤其是当存在肾小球硬化的组织学病变时。本文回顾了已发表的文献，并简要讨论了这些肾病可能的发病机制：要么是性质尚未完全确定的蛋白质沉积，要么是滤过的轻链引起的系膜改变。
