Berkes I, Jovanovic V, Zivanov-Stakić D
Nucl Med (Stuttg). 1975 Dec 15;14(4):374-80.
A simple and rapid method for the synthesis of 3-chloromercury-2-hydroxipropyl-urea has been described. It has been concluded that highest yields are obtained by the synthesis of 197HgO and allyl urea in the ratio of 2.5 : 1. Stability of the final preparation was investigated after thermal sterilization and standing at room temperature. It has been proved that the inorganic mercury-197 is not released. Radiochemical purity was controlled by chromatographic method using pyridine, n-butanol and water (3 : 10 : 3 v/v) as a solvent. The results obtained indicate that the preparation is applicable for human use.
已描述了一种合成3-氯汞基-2-羟丙基脲的简单快速方法。得出的结论是，按2.5:1的比例合成197HgO和烯丙基脲可获得最高产率。对最终制剂进行热灭菌并在室温下放置后，研究了其稳定性。已证明无机汞-197不会释放。使用吡啶、正丁醇和水（3:10:3 v/v）作为溶剂，通过色谱法控制放射化学纯度。所得结果表明该制剂适用于人体。
