Grzeszczak Władysław, Misztalski Tomasz
Katedra i Klinika Chorób Wewnetrznych, Diabetologii Wydziału Lekarskiego w Zabrzu, Slaskiej Akademii Medycznej, 41-800 Zabrze, ul. 3 Maja 13/15.
Przegl Lek. 2002;59(2):79-83.
I/D polymorphism of ACE gene is the most frequent examined polymorphism and probably very strongly connected to pathology. The majority of studies describe negative influence of allele D on frequency and course of given diseases. The result of negative effect of this allele should be visible in people with long life expectancy. To answer the question: is I/D polymorphism ACE gene responsible for long-life, a comparison was made of the genotype map of a group of 101 long-life subjects with a group of 494 younger persons. The examination used polymerase chain reaction methods. The results were calculated using the programme Statistica 5.1 PL. One used the independent chi 2 test and Odds Ratio to compare the genotype map and localisation of alleles. After having made comparative examination no connection was made between I/D polymorphism ACE gene and long-life.
血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性是最常检测的多态性，可能与病理学密切相关。大多数研究描述了等位基因D对特定疾病的发病率和病程有负面影响。这种等位基因的负面影响结果在预期寿命较长的人群中应该是可见的。为了回答这个问题：ACE基因的I/D多态性是否与长寿有关，对101名长寿受试者和494名年轻人的基因型图谱进行了比较。检测采用聚合酶链反应方法。结果使用Statistica 5.1 PL程序进行计算。使用独立卡方检验和优势比来比较基因型图谱和等位基因定位。经过比较检测，ACE基因的I/D多态性与长寿之间没有关联。
