Nayler W G, Burian W
Postgrad Med J. 1975 May;51(595):350-6. doi: 10.1136/pgmj.51.595.350.
A drug-induced change in the fine morphology of the plasma membrane of heart muscle cells is described. Thus, in rabbits the chronic administration of oxyfedrine caused a marked proliferation of the plasma membrane. At the same time the mitochondria became swollen and vacuolated, and there was evidence of lysis of myofibrils. These changes are not accounted for in terms of the release of endogenous stores of catecholamines.
本文描述了药物引起的心肌细胞质膜细微形态变化。因此,在家兔中,长期给予奥昔非君会导致质膜显著增生。与此同时,线粒体肿胀并出现空泡,并有肌原纤维溶解的迹象。这些变化不能用内源性儿茶酚胺储存的释放来解释。