Rossi A, Ziacchi V, Lomanto B
Arch Mal Coeur Vaiss. 1979 Nov;72(11):1240-6.
Characteristic changes in the systolic time intervals in Stage II (WHO Classification) hypertension have been demonstrated comprising an increase in the pre ejection period (PEP), a decrease in the left ventricular ejection time (LVET) both statistically significant, and an increase in the PEP/LVET ratio. We have studied the variations brought about by effective hypotensive therapy with an alpha and beta blocking agent (Labetalol) in 15 patients over a period of 90 days, with an average dosage of 420 mg/day in three divided doses. There was no significant variations in the PEP, but the LVET which had been reduced by 7.9% returned to within 2.8% of normal, with a reduction in the PEP/LVET ratio. The variations of these systolic indices (generally considered to be the most sensitive assessment of left ventricular function) seem to show that the hypotensive effect of labetalol is not related to a reduction in cardiac efficiency.
已证实，Ⅱ期（世界卫生组织分类法）高血压患者的收缩期时间间期有特征性变化，包括射血前期（PEP）延长、左心室射血时间（LVET）缩短，两者均具有统计学意义，且PEP/LVET比值升高。我们研究了15例患者使用α和β受体阻滞剂（拉贝洛尔）进行有效降压治疗90天所带来的变化，平均剂量为每日420毫克，分三次服用。PEP无显著变化，但曾降低7.9%的LVET恢复至正常水平的2.8%以内，PEP/LVET比值降低。这些收缩期指标的变化（通常被认为是评估左心室功能最敏感的指标）似乎表明，拉贝洛尔的降压作用与心脏效率降低无关。
