Schirripa V, Attisano N, Sarica G, Grenci G, Martelli G
Minerva Med. 1982 Apr 2;73(14):845-9.
The clinical effects, the exercise test answer, the left ventricular function by polygraphyc test after administration at middle term of Metoprolol and Labetalol have been evaluated in 20 patients with moderate and non complicated essential hypertension. The study was a double blind cross-over between Metoprolol and Labetalol (270 mg/die per os). Both drugs induced a reduction of PAOS and PAOD. The exercise test induced in all patients a decrease of PAOS and PAOD, showing an improvement of strain tolerance. The normalization of PEP and non modification of LVET seem to confirm that the treatment with Metoprolol and with Labetalol, neither induces significant modification of left ventricular function.
对20例中度且无并发症的原发性高血压患者，评估了美托洛尔和拉贝洛尔中期给药后的临床效果、运动试验反应以及通过多导记录测试得到的左心室功能。该研究是美托洛尔和拉贝洛尔（口服270mg/日）之间的双盲交叉试验。两种药物均使收缩期血压和舒张期血压降低。运动试验使所有患者的收缩期血压和舒张期血压均降低，显示出应变耐受性得到改善。射血前期（PEP）的正常化以及左心室射血时间（LVET）未改变似乎证实，美托洛尔和拉贝洛尔治疗均未引起左心室功能的显著改变。
