Bates Craig G, Gujadhur Rattan K, Venkataraman D
Department of Chemistry, University of Massachusetts, Amherst 01003, USA.
Org Lett. 2002 Aug 8;4(16):2803-6. doi: 10.1021/ol0264105.
[reaction: see text] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.
