单次剂量和每日两次剂量方案下血浆苯妥英水平的波动
Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
作者信息
Vajda F J, Merory J, Bladin P F
出版信息
Proc Aust Assoc Neurol. 1975;12:61-4.
PMID:1215397
Abstract
Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.
摘要
对8例慢性难治性癫痫患者就苯妥英钠的给药频率进行了研究。当每日总药量作为单次剂量给药时，血浆水平没有过度波动，且患者的临床状态与每日给药两次时相比没有变化。
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