淋巴管生成与癌症转移。
Lymphangiogenesis and cancer metastasis.
作者信息
Stacker Steven A, Achen Marc G, Jussila Lotta, Baldwin Megan E, Alitalo Kari
机构信息
Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia.
出版信息
Nat Rev Cancer. 2002 Aug;2(8):573-83. doi: 10.1038/nrc863.
Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.
淋巴管对实体瘤的扩散至关重要，但淋巴管扩散背后的机制以及淋巴管生成（淋巴管的生长）在肿瘤转移中的作用尚不清楚。本文综述了近期的实验和临床病理数据，这些数据表明，刺激肿瘤中淋巴管生成的生长因子与转移过程的增强有关。
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