Junod A F
Schweiz Med Wochenschr. 1975 Dec 6;105(49):1656-8.
The lung is the site of a number of reactions affecting vasoactive substances: hydrolysis of angiotensin I, bradykinin and ATP, occurring at the surface of endothelial cell; uptake and intracellular metabolism of 5-hydroxytryptamine and norepinephrine; and intracellular oxidation of prostaglandins. Mediators, including prostaglandins, histamine and SRS-A (slow reacting substance of anaphylaxis), can also be released from the lung. The possible implications of these recent findings are analysed.
血管紧张素I、缓激肽和三磷酸腺苷(ATP)在内皮细胞表面发生水解;5-羟色胺和去甲肾上腺素的摄取及细胞内代谢;以及前列腺素的细胞内氧化。介质,包括前列腺素、组胺和过敏反应慢反应物质(SRS-A),也可从肺中释放。分析了这些最新发现可能产生的影响。