Penicillin and essential fatty acid supplementation in schizophrenia.

There is evidence of a prostaglandin deficiency in schizophrenia, possibly particularly of the 1 series. Treatment of neuroleptic-resistant schizophrenics with essential fatty acids and penicillin in an attempt to increase synthesis of 1 series prostaglandins had a therapeutic effect in six severely ill patients. Two detailed case histories are described.