Heleniak E P, Lamola S W
Med Hypotheses. 1986 Apr;19(4):333-8. doi: 10.1016/0306-9877(86)90106-4.
At least two groups of schizophrenics will be described. One such group may have a mutant delta-6-desaturase which prefers the omega-6-series essential fatty acids over the omega-3 series essential fatty acids resulting in low cis-linoleic acid blood levels. This subgroup may be related to the low histamine type schizophrenia. In contrast, we describe the possible existence of another group of schizophrenic patients with elevated cis-linoleic acid blood levels, elevated fasting insulin levels, elevated EGOT and urinary kryptopyrolle termed "delta-6-pyroluria." The etiology of this group may be due to a block instead of a mutant delta-6-desaturase. The elevated fasting insulin level may be an attempt to overcome the malfunctioning pathway.
至少将描述两组精神分裂症患者。其中一组可能具有突变的δ-6-去饱和酶，该酶更喜欢ω-6系列必需脂肪酸而非ω-3系列必需脂肪酸，导致血液中顺式亚油酸水平较低。这一亚组可能与低组胺型精神分裂症有关。相比之下，我们描述了另一组精神分裂症患者可能的存在，他们血液中顺式亚油酸水平升高、空腹胰岛素水平升高、EGOT升高以及尿液中存在称为“δ-6-吡咯尿症”的尿犬尿喹啉酸。这一组的病因可能是由于一种阻断而非突变的δ-6-去饱和酶。空腹胰岛素水平升高可能是试图克服功能失调的途径。
