Rubenstein James, Fischbein Nancy, Aldape Ken, Burton Eric, Shuman Marc
Division of Hematology/Oncology, University of California, San Francisco 94143, USA.
J Neurooncol. 2002 May;58(1):53-6. doi: 10.1023/a:1015887312455.
Hemorrhage at presentation in primary CNS lymphoma is exceedingly rare. We describe a patient with primary CNS lymphoma who presented with seizures and was found to have an intracerebral hemorrhage which prompted a cerebral angiogram. Ultimately pathologic evaluation of the lesion revealed a highly cellular B-cell lymphoma with marked hypervascularity and intense expression of vascular endothelial growth factor (VEGF). A review of four other recent cases of primary CNS lymphoma at our institution revealed less-intense VEGF immunoreactivity. This is the first report of VEGF expression in primary CNS lymphoma. The potential significance of VEGF expression with respect to the biology of this tumor is discussed.
原发性中枢神经系统淋巴瘤初诊时出现出血极为罕见。我们描述了一名患有原发性中枢神经系统淋巴瘤的患者，该患者以癫痫发作就诊，经检查发现有脑出血，进而进行了脑血管造影。最终，病变的病理评估显示为高度细胞性B细胞淋巴瘤，伴有明显的血管增生和血管内皮生长因子（VEGF）的强烈表达。对我们机构最近另外4例原发性中枢神经系统淋巴瘤病例的回顾显示，VEGF免疫反应性较弱。这是原发性中枢神经系统淋巴瘤中VEGF表达的首次报道。本文讨论了VEGF表达在该肿瘤生物学方面的潜在意义。
