Krauzlis Richard, Dill Natalie
Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Neuron. 2002 Jul 18;35(2):355-63. doi: 10.1016/s0896-6273(02)00756-0.
We have examined the role of the superior colliculus (SC) in choosing targets for pursuit and saccades by comparing neuronal activity at sites representing the possible choices. After recording during a two-alternative forced-choice paradigm, we measured the difference in activity of the populations representing the two choices by computing receiver operating characteristic (ROC) curves on a millisecond timescale. A signal indicating the correct choice emerged from noise over time, forming a tradeoff between speed and accuracy. The observed performance corresponded to particular points along the predicted speed-accuracy curves-pursuit emphasizing speed and saccades emphasizing accuracy. These results show that activity from the same set of neurons in the superior colliculus can predict target choices for both pursuit and saccades.
我们通过比较代表可能选择的位点的神经元活动，研究了上丘（SC）在选择追踪和扫视目标中的作用。在双选强制选择范式下进行记录后，我们通过在毫秒时间尺度上计算接受者操作特征（ROC）曲线，测量了代表两种选择的群体活动差异。随着时间的推移，一个指示正确选择的信号从噪声中出现，在速度和准确性之间形成了一种权衡。观察到的表现对应于预测的速度-准确性曲线上的特定点——追踪强调速度，扫视强调准确性。这些结果表明，上丘中同一组神经元的活动可以预测追踪和扫视的目标选择。
