Avorn Jerry, Winkelmayer Wolfgang C, Bohn Rhonda L, Levin Raisa, Glynn Robert J, Levy Elliot, Owen William
Division of Pharmacoepidemiology and Pharmacoeconomics, Division of Nephrology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
J Clin Epidemiol. 2002 Jul;55(7):711-6. doi: 10.1016/s0895-4356(02)00415-8.
We sought to determine whether late referral to a nephrologist in patients with chronic renal failure influences the adequacy of vascular access for hemodialysis. We analyzed data describing all health care encounters for all Medicare and Medicaid patients with end-stage renal failure in New Jersey between January 1991 and June 1996. Patients were required to have been diagnosed with renal disease at least 1 year prior to onset of hemodialysis. In the resulting cohort of 2,398 incident hemodialysis patients, 35% had their first nephrologist consultation < or =90 days prior to initiation of dialysis. After controlling for demographic characteristics, socio-economic status and underlying renal disease, we found that patients who were referred to a nephrologist >90 days prior to onset of hemodialysis were 38% more likely to have undergone predialysis vascular access surgery than those who were referred to a nephrologist < or =90 days before dialysis [OR: 1.38; 95% CI (1.15; 1.64)]. Similarly, patients referred late were 42% more likely to require central venous access for hemodialysis compared to those seen by a nephrologist early [OR: 1.42; 95% CI (1.17; 1.71)]. Inadequate development of vascular access for renal replacement therapy in patients with late nephrologist referral unnecessarily contributes to the burden of disease experienced by this vulnerable patient population.
我们试图确定慢性肾衰竭患者延迟转诊至肾病科医生是否会影响血液透析血管通路的充分性。我们分析了1991年1月至1996年6月期间新泽西州所有终末期肾衰竭的医疗保险和医疗补助患者的所有医疗保健接触数据。患者需在开始血液透析前至少1年被诊断患有肾病。在最终的2398例新接受血液透析的患者队列中,35%在开始透析前≤90天首次咨询肾病科医生。在控制了人口统计学特征、社会经济地位和潜在肾病后,我们发现,在开始血液透析前>90天转诊至肾病科医生的患者,比起在透析前≤90天转诊的患者,接受透析前血管通路手术的可能性高38%[比值比:1.38;95%置信区间(1.15;1.64)]。同样,与早期咨询肾病科医生的患者相比,延迟转诊的患者进行血液透析需要中心静脉通路的可能性高42%[比值比:1.42;95%置信区间(1.17;1.71)]。肾病科医生转诊延迟的患者,肾脏替代治疗的血管通路发育不足,不必要地加重了这一脆弱患者群体的疾病负担。