以β-D-葡聚糖为基质制备与霍乱弧菌01脂多糖的亚细胞缀合物。
Preparation of a subcellular conjugate with the lipopolysaccharide from Vibrio cholerae 01 using beta-D-glucan as matrix.
作者信息
Machová Eva, Bystrický Slavomír, Gáliková Anna, Kogan Grigorij
机构信息
Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 842 38 Bratislava, Slovakia.
出版信息
Eur J Med Chem. 2002 Aug;37(8):681-7. doi: 10.1016/s0223-5234(02)01392-2.
Abstract
A conjugate consisting of detoxified lipopolysaccharide of Vibrio cholerae, a carrier polysaccharide matrix and an immunogenic protein has been synthesised and the reaction conditions have been optimised for obtaining a high degree of conjugation. The obtained construct showed reactivity with the antibodies against V. cholerae and can serve as a prospective candidate for preparation of subcellular anti-cholera vaccine.
摘要
已合成一种由霍乱弧菌解毒脂多糖、载体多糖基质和免疫原性蛋白组成的偶联物，并优化了反应条件以实现高度偶联。所得构建体显示出与抗霍乱弧菌抗体的反应性，可作为制备亚细胞抗霍乱疫苗的潜在候选物。
Zotero 插件