对甲氧基苄基异硫氰酸酯对淋病奈瑟菌、杜克雷嗜血杆菌及其他微生物的活性。

The activity of p-methoxybenzylisothiocyanate against Neisseria gonorrhoeae, Haemophilus ducreyi, and other microorganisms.

作者信息

Swart Henk, Van Dyk Sandra, Malan Sarel F

机构信息

Pharmaceutical Chemistry, Potchefstroomse Universiteit vir Christelike Hoër Onderwys, Potchefstroom, South Africa.

出版信息

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2435-7. doi: 10.1016/s0960-894x(02)00437-7.

DOI:10.1016/s0960-894x(02)00437-7

PMID:12161151

Abstract

p-Methoxybenzylisothiocyanate was isolated from Lepidium bonariense and found to be responsible for the plants antimicrobial and STD activity. MIC determinations were conducted for p-methoxybenzylisothiocyanate on Haemophilus ducreyi, Neisseria gonorrheae, Candida albicans, Bacillus subtilus, Micrococcus luteus, Staphylococcus aureus, Enterobacter sp., Escherichia coli, Klebsiella pneumoniae, and Psuedomanas aeruginosa. An in vitro cellular toxicity assay showed that at 100 microM (17,9 microg/mL) p-methoxybenzylisothiocyanate is not toxic to living cells.

摘要

对甲氧基苄基异硫氰酸酯是从阿根廷独行菜中分离出来的，发现它具有该植物的抗菌和抗性传播疾病活性。对甲氧基苄基异硫氰酸酯对杜克雷嗜血杆菌、淋病奈瑟菌、白色念珠菌、枯草芽孢杆菌、藤黄微球菌、金黄色葡萄球菌、肠杆菌属、大肠杆菌、肺炎克雷伯菌和铜绿假单胞菌进行了最低抑菌浓度测定。体外细胞毒性试验表明，在100微摩尔（17.9微克/毫升）时，对甲氧基苄基异硫氰酸酯对活细胞无毒。