急性细菌性鼻窦炎的短疗程治疗：五日环丙沙星治疗与七日环丙沙星治疗对比

Short treatment durations for acute bacterial rhinosinusitis: Five days of gemifloxacin versus 7 days of gemifloxacin.

作者信息

Ferguson Berrylin J, Anon Jack, Poole Michael D, Hendrick Kim, Gilson Martyn, Seltzer Elyse G

机构信息

University of Pittsburgh School of Medicine, Ear, Nose, and Throat Specialists of Northwestern PA, 15213, USA.

出版信息

Otolaryngol Head Neck Surg. 2002 Jul;127(1):1-6. doi: 10.1067/mhn.2002.126593.

DOI:10.1067/mhn.2002.126593

PMID:12161723

Abstract

OBJECTIVE

The primary objective of this study was to demonstrate the clinical and radiologic efficacy of 5 days compared with 7 days of gemifloxacin therapy in the treatment of acute bacterial rhinosinusitis (ABRS).

STUDY DESIGN

In this prospective, double-blind, multicenter, parallel-group study, adult patients presenting with ABRS were randomized to receive gemifloxacin 320 mg once daily for either 5 days (n = 218) or 7 days (n = 203).

RESULTS

For the primary efficacy end point, clinical response to therapy at follow-up, 5 days of therapy with gemifloxacin was as effective as 7 days of therapy (per-protocol population; treatment difference 0.44%; 95% confidence interval [CI], -6.54 to 7.41). Five and 7 days of treatment with gemifloxacin were well tolerated.

CONCLUSION AND SIGNIFICANCE

The clinical efficacy of gemifloxacin 320 mg daily for 5 days is at least as good as the efficacy of gemifloxacin 320 mg daily for 7 days in the treatment of ABRS.

摘要