鼻眶及鼻眶脑型毛霉菌病

Rhino-orbital and rhino-orbito-cerebral mucormycosis.

作者信息

Talmi Yoav P, Goldschmied-Reouven Anna, Bakon Mati, Barshack Iris, Wolf Michael, Horowitz Zeev, Berkowicz Miriam, Keller Nathan, Kronenberg Jona

机构信息

Departments of Otolaryngology-Head and Neck Surgery, The Chaim Sheba Medical Center, Israel.

出版信息

Otolaryngol Head Neck Surg. 2002 Jul;127(1):22-31. doi: 10.1067/mhn.2002.126587.

DOI:10.1067/mhn.2002.126587

PMID:12161726

Abstract

BACKGROUND

Rhino-orbito-cerebral mucormycosis (ROCM) is a devastating infection of immunocompromised hosts. We present our experience with 19 ROCM cases and attempt to define preferred diagnostic and treatment protocols.

METHODS

All had tissue biopsies obtained studied by direct smear, histologic studies, and cultures. Imaging was obtained in 14 cases.

RESULTS

Sixteen patients presented between August and November. Six had mixed fungal infections. Seven patients had end-stage underlying disease or infection and did not undergo surgery and 4 had an indolent form of disease. Patients were treated by surgery and by amphotericin B. The overall survival was 47%.

CONCLUSIONS

ROCM may have seasonal incidence peaking in the fall and early winter. The therapeutic approach should be unchanged in cases of mixed fungal infections. Amphotericin B with aggressive debridement remains the mainstay of treatment. Early recognition and treatment are essential. A presentation and survival-dependent classification of ROCM are offered.

摘要