多发性骨髓瘤的新型疗法。

Novel therapies for multiple myeloma.

作者信息

Ryoo Joan J, Cole Craig Emmitt, Anderson Kenneth C

机构信息

Harvard Medical School, MA, USA.

出版信息

Blood Rev. 2002 Sep;16(3):167-74. doi: 10.1016/s0268-960x(02)00009-7.

DOI:10.1016/s0268-960x(02)00009-7

PMID:12163002

Abstract

Multiple myeloma (MM) continues to evade cure by conventional therapies, increasing the urgency for new, biologically based treatments. Reviewed in this discussion are novel chemotherapies under clinical trial that capitalize upon greater comprehension of tumor pathophysiology. In targeting tumor biology, these therapies serve as a model of treatment with great potential for improving outcomes in patients with MM.

摘要

多发性骨髓瘤（MM）仍然难以通过传统疗法治愈，这增加了对新型生物疗法的迫切需求。本讨论回顾了正在进行临床试验的新型化疗方法，这些方法利用了对肿瘤病理生理学的更深入理解。在针对肿瘤生物学方面，这些疗法是一种具有巨大潜力改善MM患者治疗结果的治疗模式。