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[高氧对脑和肝线粒体钙转运的影响]

[Effect of hyperoxia on calcium transport in mitochondria of brain and liver].

作者信息

Matsynin V V, Fedoriv O M

出版信息

Ukr Biokhim Zh. 1975 May-Jun;47(3):358-61.

PMID:1216352
Abstract

The active and passive transport of radioactive calcium was studied in experiments on the brain and liver mitochondria, homogenates of brain and erythrocytes of albino rats subjected to the toxic effect of oxygen under pressure. The processes of the Ca2+ active transport preparations under examination are established to be inhibited after the effect of hyperoxia. The passive transport is considerably less dependent on the previous effect of oxygen. A conclusion is drawn on the prevailing sensitivity of the calcium energy-dependent transport to the damaging effect of hyperoxia.

摘要

在对白化病大鼠的大脑、肝脏线粒体、大脑匀浆和红细胞进行加压氧中毒效应实验中,研究了放射性钙的主动转运和被动转运。结果表明,在所研究的Ca2+主动转运制剂中,高氧作用后这些过程受到抑制。被动转运对先前的氧作用依赖性小得多。得出结论:钙的能量依赖性转运对高氧损伤作用更为敏感。

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