痘苗病毒I7L基因产物是核心蛋白酶。
The vaccinia virus I7L gene product is the core protein proteinase.
作者信息
Byrd Chelsea M, Bolken Tove' C, Hruby Dennis E
机构信息
Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA.
出版信息
J Virol. 2002 Sep;76(17):8973-6. doi: 10.1128/jvi.76.17.8973-8976.2002.
Abstract
Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.
摘要
痘苗病毒（VV）核心蛋白的成熟是产生感染性病毒粒子所必需的。VV的G1L和I7L基因产物是病毒核心蛋白酶（vCPP）的主要候选对象。通过瞬时表达分析，获得的数据表明I7L基因产物及其编码的半胱氨酸蛋白酶活性负责vCPP活性。
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