Thiel Christiane M, Friston Karl J, Dolan Raymond J
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1 3BG, United Kingdom.
Neuron. 2002 Aug 1;35(3):567-74. doi: 10.1016/s0896-6273(02)00801-2.
The factors that influence experience-dependent plasticity in the human brain are unknown. We used event-related functional magnetic resonance imaging (fMRI) and a pharmacological manipulation to measure cholinergic modulation of experience-dependent plasticity in human auditory cortex. In a differential aversive conditioning paradigm, subjects were presented with high (1600 Hz) and low tones (400 Hz), one of which was conditioned by pairing with an electrical shock. Prior to presentation, subjects were given either a placebo or an anticholinergic drug (0.4 mg iv scopolamine). Experience-dependent plasticity, expressed as a conditioning-specific enhanced BOLD response, was evident in auditory cortex in the placebo group, but not with scopolamine. This study provides in vivo evidence that experience-dependent plasticity, evident in hemodynamic changes in human auditory cortex, is modulated by acetylcholine.
影响人类大脑中经验依赖性可塑性的因素尚不清楚。我们使用事件相关功能磁共振成像（fMRI）和药物操作来测量人类听觉皮层中经验依赖性可塑性的胆碱能调节。在差异厌恶条件反射范式中，向受试者呈现高音（1600赫兹）和低音（400赫兹），其中一个通过与电击配对进行条件反射。在呈现之前，受试者被给予安慰剂或抗胆碱能药物（静脉注射0.4毫克东莨菪碱）。在安慰剂组的听觉皮层中，以条件反射特异性增强的BOLD反应表示的经验依赖性可塑性很明显，但在使用东莨菪碱时则不明显。这项研究提供了体内证据，表明在人类听觉皮层血流动力学变化中明显的经验依赖性可塑性受乙酰胆碱调节。
