Fekete E, Szidonya J
Acta Biol Acad Sci Hung. 1979;30(1):47-57.
An X-linked mutant of Drosophila melanogaster was isolated which was completely unable to fly. The map position of the mutation is 43 +/- 0.1. Gynandromorph analysis indicated that the mutation is autonomously expressed in the flight muscle. Fate-map data show that the focus of the mutation lies close to the ventral midline of the blastoderm. Flightlessness appears to be the result of abnormalities of the thoracic musculature, including highly irregular arrangement of the fibrils, lack of the normal striation pattern and abnormal structure of the mitochondria. X-ray microanalysis (EDAX) demonstrates a pronounced difference in the distribution of calcium in mutant and wild-type flight muscle at the fine-structural level. We propose that an abnormal calcium distribution in the mutant may be associated with the ultrastructural abnormalities and ultimately responsible for the flightless phenotype.
分离出一种黑腹果蝇的X连锁突变体，它完全无法飞行。该突变的图谱位置为43±0.1。雌雄嵌合体分析表明，该突变在飞行肌中自主表达。命运图谱数据显示，突变的焦点位于胚盘腹中线附近。无法飞行似乎是胸肌组织异常的结果，包括肌原纤维排列高度不规则、缺乏正常的条纹模式以及线粒体结构异常。X射线微分析（能谱分析）表明，在精细结构水平上，突变型和野生型飞行肌中钙的分布存在显著差异。我们认为，突变体中异常的钙分布可能与超微结构异常有关，并最终导致无法飞行的表型。
