Hagihara Reiko, Meno Aki, Arita Hideko, Hanaoka Kazuo
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655.
Masui. 2002 Jul;51(7):777-9.
We report a case of effective treatment with clonidine ointment for herpetic neuralgia in a child. Clonidine hydrochloride is an alpha 2-agonist. It is generally administered intravenously, intramuscularly, intrathecally and orally. However, there have been only a few reports on transdermal usage. In our department, we have investigated the analgesic effect of topical application of clonidine in adults, and we have obtained sufficient evidence on the effects of clonidine. Therefore, we decided to use clonidine to a child. A 9-year-old child who had undergone BMT and developed herpes zoster was experiencing severe pain, itch, and insomnia. Many drugs were ineffective in relieving the pain, itch, and insomnia. To remove the symptoms, we tried clonidine ointment. Immediate improvement was observed in all the symptoms. Therefore, clonidine ointment was thought to be effective and we decided to prescribe clonidine ointment and amitriptyline hydrochloride. The application of clonidine showed no side effects such as bradycardia and low blood pressure. We conclude that clonidine can be administered to children without causing side effects.
我们报告了1例可乐定软膏有效治疗儿童疱疹后神经痛的病例。盐酸可乐定是一种α2激动剂。它通常通过静脉、肌肉、鞘内及口服给药。然而,关于其经皮给药的报道较少。在我们科室,我们已经研究了可乐定局部应用于成人的镇痛效果,并且已经获得了关于可乐定作用的充分证据。因此,我们决定将可乐定用于一名儿童。一名9岁儿童接受了骨髓移植并患带状疱疹,正经历着严重的疼痛、瘙痒和失眠。许多药物在缓解疼痛、瘙痒和失眠方面均无效。为消除这些症状,我们尝试使用可乐定软膏。所有症状均立即得到改善。因此,认为可乐定软膏有效,我们决定开具可乐定软膏和盐酸阿米替林。使用可乐定未出现心动过缓和低血压等副作用。我们得出结论,可乐定可用于儿童且不会引起副作用。