Gustavsson A, Olofsson T, Olsson I
Acta Haematol. 1979;62(5-6):241-6. doi: 10.1159/000207581.
Sequential studies in acute myeloid leukemia of bone marrow cells in agar culture showed striking fluctuations of colony and cluster formation during induction of remission. These oscillations may be initiated by recruitment of resting leukemic and normal cells upon chemotherapeutic perturbation. Striking oscillations of the colony and cluster formation occurred also during remission with or without maintenance therapy, but with a longer periodicity as compared sto the phase of induction of remission. Oscillations of the marrow growth capacity during remission may reflect potential relapses where the outcome depends on proliferative advantages of the normal or leukemic cell clone.
对急性髓系白血病患者骨髓细胞进行琼脂培养的序贯研究显示，在诱导缓解期间，集落和集簇形成存在显著波动。这些波动可能是由于化疗扰动促使静止的白血病细胞和正常细胞募集所致。在缓解期，无论有无维持治疗，集落和集簇形成也会出现显著波动，但与诱导缓解期相比，周期更长。缓解期骨髓生长能力的波动可能反映了潜在的复发情况，其结果取决于正常或白血病细胞克隆的增殖优势。
