Enomoto Fuyuki, Andou Ichirou, Nagaoka Isao, Ichikawa Ginichirou
Department of Otorhinolaryngology, Junntendo University School of Medicine, 2-1-1 Hongou Bunkyou-ku, Tokyo 113-8421, Japan.
Auris Nasus Larynx. 2002 Jul;29(3):267-9. doi: 10.1016/s0385-8146(02)00015-9.
To elucidate the mechanisms involved in the action of new macrolides on chronic sinusitis, we examined the effects of clarithromycin (CAM) and roxiythromycin (RXM) on the expression of adhesion molecules (L-selectin and Mac-1) on peripheral blood neutrophils of individuals with chronic sinusitis. The administration of CAM and RXM slightly inhibited the down-regulation of L-selectin expression on neutrophils induced by interleukin (IL)-8 stimulation. Furthermore, the administration of CAM strongly inhibited the IL-8-induced up-regulation of Mac-1 expression on neutrophils. These observations suggest that the new macrolides such as CAM and RXM may affect the functions of neutrophils in chronic sinusitis by modulating the expression of L-selectin and Mac-1 molecules on neutrophils, thereby attenuating the adhesion of neutrophils.
