Quantitative evaluation of angiogenesis in laryngeal cancer by digital image measurement of the vessel density.

作者信息

Krecicki Tomasz, Dus Danuta, Kozlak Joanna, Tarnawski Wojciech, Jelen Michal, Zalesska-Krecicka Maria, Szkudlarek Teresa

机构信息

Department of Otolaryngology, Medical University of Wrocław, ul. Smoleńskiego 4, 51-607 Wrocław, Poland.

出版信息

Auris Nasus Larynx. 2002 Jul;29(3):271-6. doi: 10.1016/s0385-8146(01)00149-3.

DOI:10.1016/s0385-8146(01)00149-3

PMID:12167450

Abstract

OBJECTIVE

the aim of our study was determination of the relationship between angiogenesis and clinical as well as histological features in laryngeal cancer.

METHODS

we used two different methods of estimation of the amount of microvessels in the series of 55 cases, e.g. classical count of endothelial cells group (h-MVD) and digital image measurement of the vessel density (VD).

RESULTS

neither h-MVD nor VD correlated significantly with clinical features of the tumour. The results of VD examination correlated significantly with the existence of nodal metastases (P=0.02). The relationship between h-MVD and N status was on the statistical borderline (P=0.07). Multivariate analysis of Cox's proportional hazards model revealed that only N status correlated significantly with patients' survival.

CONCLUSION

our results indicate that measurements of angiogenesis in laryngeal cancer may be of some value in predicting N status in laryngeal cancer patients. This issue should be confirmed in prospective studies.

摘要