Zayets T L, Kotkina T I
Vopr Med Khim. 1975 Jul-Aug;21(4):380-2.
Degradation of proteins in liver tissue slices, estimated by liberation of 14C-glycine, was increased in the animals which were subjected to burns. The cathepsin D activity was found to be simultaneously increased in extracts of the liver tissue. In burnt rats, administered with an inhibitor of trypsin-like enzymes (contrical) during 8 days after the burning, the rates of protein degradation and the values of cathepsin D activity approached those characteristics for the normal animals. Addition of the inhibitor into incubation samples did not effect degradation of liver tissue proteins and the enzymatic activity.
通过释放14C - 甘氨酸来估计，烧伤动物肝脏组织切片中的蛋白质降解增加。发现肝脏组织提取物中的组织蛋白酶D活性同时增加。在烧伤大鼠烧伤后8天内给予类胰蛋白酶抑制剂（抑肽酶），蛋白质降解速率和组织蛋白酶D活性值接近正常动物的特征。将该抑制剂添加到孵育样品中不影响肝脏组织蛋白质的降解和酶活性。
