Anagnostou C, Nicolaou I, Demopoulos V J
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece.
Pharmazie. 2002 Jul;57(7):435-7.
[5-(4-Pyrrol-1-yl-benzoyl)-1H-pyrrol-2-yl)]-acetic acid was synthesized in a Vilsmeier-Haack process and by other methods. The compound was found to inhibit the enzyme aldose reductase as well as the glycation process of proteins and could therefore be useful for the treatment of various pathological conditions.
[5-(4-吡咯-1-基-苯甲酰基)-1H-吡咯-2-基]乙酸是通过维尔斯迈尔-哈克反应及其他方法合成的。该化合物被发现能够抑制醛糖还原酶以及蛋白质的糖基化过程,因此可能对治疗各种病理状况有用。