Suppr超能文献

[5-(4-吡咯-1-基-苯甲酰基)-1H-吡咯-2-基]-乙酸的合成及其对醛糖还原酶和蛋白质糖基化抑制活性的体外研究

Synthesis of [5-(4-pyrrol-1-yl-benzoyl)-1 H-pyrrol-2-yl)]-acetic acid and in vitro study of its inhibitory activity on aldose reductase enzyme and on protein glycation.

作者信息

Anagnostou C, Nicolaou I, Demopoulos V J

机构信息

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece.

出版信息

Pharmazie. 2002 Jul;57(7):435-7.

Abstract

[5-(4-Pyrrol-1-yl-benzoyl)-1H-pyrrol-2-yl)]-acetic acid was synthesized in a Vilsmeier-Haack process and by other methods. The compound was found to inhibit the enzyme aldose reductase as well as the glycation process of proteins and could therefore be useful for the treatment of various pathological conditions.

摘要

[5-(4-吡咯-1-基-苯甲酰基)-1H-吡咯-2-基]乙酸是通过维尔斯迈尔-哈克反应及其他方法合成的。该化合物被发现能够抑制醛糖还原酶以及蛋白质的糖基化过程,因此可能对治疗各种病理状况有用。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验