Expression of DNA topoisomerase IIalpha in oligodendroglioma.

作者信息

Bredel Markus, Gatterbauer Brigitte, Birner Peter, Haberler Christine, Ströbel Thomas, Budka Herbert, Rössler Karl, Hainfellner Johannes A

机构信息

Institute of Neurology, Department of Neurosurgery, University of Vienna, Wien, Austria.

出版信息

Anticancer Res. 2002 Mar-Apr;22(2B):1301-4.

BACKGROUND

DNA Topoisomerase ha (Topo flu) is a nuclear enzyme whose expression levels are related to tumor cell growth and to resistance to anticancer chemotherapy.

MATERIALS AND METHODS

Topo ha expression was assessed immunohistochemically in 60 surgical specimens of 47 consecutive oligodendroglioma patients. Expression levels were correlated with the MIB-1 proliferation index and with patient outcome.

RESULTS

Topo flu expression ranges from 0.3 to 40.1% and is significantly associated with MIB-) staining. There is a weak trend to a higher expression of Topo flu in anaplastic oligodendrogliomas (p = 0.08). Topo ha expression is not related to patient outcome.

CONCLUSION

Topo flu expression appears to serve as a marker for tumor growth in human oligodendrogliomas. The widely vaiying expression levels of Topo ha in oligodendroglioma suggest this enzyme could be used for targeted selection of patients for Topo flu-interfering chemotherapy.