Bosso P, Miglietta C
Arch Sci Med (Torino). 1979 Oct-Dec;136(4):631-42.
During a review of the relevant literature, the view is expressed that the term "monoclonal" expresses no more than an operative concept. A classification of the benign monoclonal gammopathies is proposed in accordance with their aetiopathogenesis. Stress is laid on the importance of antigen stimuli and self-maintenance of the tumour mass below a certain number of cells. Reference is made to the possible typical symptomatology and criteria for the differential diagnosis of myeloma and Waldenström's disease are put forward. Inter alia, emphasis is placed on the little significance of Bence-Jones proteinuria for the purpose of differentiation. Models of atypical behaviour are presented.
在对相关文献进行综述时，有人认为“单克隆”一词不过表达了一个操作概念。根据良性单克隆丙种球蛋白病的病因发病机制提出了一种分类方法。强调了抗原刺激和肿瘤细胞数量低于一定水平时自我维持的重要性。提到了可能的典型症状，并提出了骨髓瘤和华氏巨球蛋白血症的鉴别诊断标准。特别强调了本周氏蛋白尿在鉴别诊断中的意义不大。还介绍了非典型行为的模型。
