Endo M, Yamaki S, Hata M, Saiki Y, Tabayashi K
Department of Cardiovascular Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Pediatr Cardiol. 2002 Jul-Aug;23(4):420-5. doi: 10.1007/s00246-002-1479-3.
The relation of pulmonary hemodynamics to pathological change in the pulmonary vasculature was examined in a model of unilateral pulmonary venous (PV) obstruction. The left upper pulmonary vein (A group, n=6) or both the left upper and left lower pulmonary veins (B group, n=6) of two-week-old piglets were banded; the control group (n=6) was sham operated. At eight weeks after PV banding, mean pulmonary arterial pressure was highest in the B group, intermediate in the A group and lowest in the control group. In all groups, the media of the pulmonary artery was equally thickened in both lungs, whereas the media of the pulmonary vein was thickened only in those lung lobes having stenotic pulmonary veins. For all animals from three groups, left pulmonary arterial wedge pressure (PAWP) correlated with medial thickness of the pulmonary arteries of the right lung (r=0.76, p=0.003), the left upper lobe (r=0.54, p<0.03), the left lower lobe (r=0.49, p=0.04). This finding suggests that the pathogenesis of PAWP-related medial thickening of the bilateral lung pulmonary artery begins with the sensing by the bilateral lung of PV pressure buildup in the unilateral lung.
在单侧肺静脉阻塞模型中，研究了肺血流动力学与肺血管病理变化之间的关系。对两周龄仔猪的左上肺静脉（A组，n = 6）或左上和左下肺静脉（B组，n = 6）进行结扎；对照组（n = 6）进行假手术。肺静脉结扎后8周，B组平均肺动脉压最高，A组次之，对照组最低。在所有组中，两肺肺动脉中膜均同等增厚，而肺静脉中膜仅在有狭窄肺静脉的肺叶中增厚。对于三组所有动物，左肺动脉楔压（PAWP）与右肺（r = 0.76，p = 0.003）、左上叶（r = 0.54，p < 0.03）、左下叶（r = 0.49，p = 0.04）肺动脉中膜厚度相关。这一发现表明，与PAWP相关的双侧肺肺动脉中膜增厚的发病机制始于双侧肺对单侧肺静脉压力升高的感知。
