肉毒杆菌毒素治疗肛裂十年经验
Ten years' experience with botulin toxin in anal fissure.
作者信息
Jost Wolfgang H
机构信息
Department of Neurology and Clinical Neurophysiology, Deutsche Klinik für Diagnostik, Aukammallee 33, 65191 Wiesbaden, Germany.
出版信息
Int J Colorectal Dis. 2002 Sep;17(5):298-302. doi: 10.1007/s00384-002-0398-3. Epub 2002 Apr 27.
BACKGROUND AND AIMS
Botulin toxin therapy has become established for various indications over the past 20 years. Treatment of anal fissure with botulin toxin began 10 years ago, and since then numerous studies with more than 300 patients have been published.
RESULTS
The healing rate in uncomplicated chronic anal fissure is about 60-80%. The injection is well tolerated, can be administered on an outpatient basis, and causes no chronic lesion of the continence organ. Botulin toxin therefore offers alternative mode for treating uncomplicated anal fissure with increased sphincter tone when conservative measures fail.
CONCLUSION
Potential candidates for surgery should be aware not only of the risks involved but should also of the existence of an alternative treatment using with botulin toxin.
背景与目的
在过去20年中，肉毒毒素疗法已被确立用于多种适应症。肉毒毒素治疗肛裂始于10年前，自那时起已发表了针对300多名患者的大量研究。
结果
单纯性慢性肛裂的愈合率约为60%-80%。注射耐受性良好，可在门诊进行，且不会导致控便器官的慢性病变。因此，当保守治疗失败时，肉毒毒素为治疗括约肌张力增加的单纯性肛裂提供了一种替代方法。
结论
潜在的手术候选者不仅应了解其中涉及的风险，还应知晓存在使用肉毒毒素的替代治疗方法。
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