Jost Wolfgang H
Dept. of Neurology, Deutsche Klinik für Diagnostik, Aukammallee 33, 65191, Wiesbaden, Germany.
J Neurol. 2006 Feb;253 Suppl 1:I16-20. doi: 10.1007/s00415-006-1104-0.
Local administration of botulinum toxin (BoTx) inhibits presynaptic acetylcholine release. All cholinergically innervated muscles and glands can be paralyzed accordingly. Studies on the application of BoTx in multiple sclerosis have shown good results for focal spasticity, in particular, of the extremities. The first promising data were published on bladder disorders, especially with regard to detrusor sphincter dyssynergia and detrusor hyperreflexia. Hyperhidrosis, hypersalivation and proctologic symptoms might be other areas of application. Approval, however, has been greatly restricted which limits the therapeutic range of use.
局部注射肉毒杆菌毒素（BoTx）可抑制突触前乙酰胆碱释放。相应地，所有受胆碱能神经支配的肌肉和腺体都会麻痹。关于BoTx在多发性硬化症中的应用研究表明，其对局部痉挛，尤其是肢体痉挛有良好效果。关于膀胱功能障碍，尤其是逼尿肌括约肌协同失调和逼尿肌反射亢进的首批有前景的数据已发表。多汗症、唾液分泌过多和直肠症状可能是其他应用领域。然而，其获批情况受到极大限制，这限制了其治疗应用范围。
