一种来自大肠杆菌的新型核糖核酸内切酶。核糖核酸酶N。
A new endoribonuclease from Escherichia coli. Ribonuclease N.
作者信息
Misra T K, Rhee S, Apirion D
出版信息
J Biol Chem. 1976 Dec 10;251(23):7669-74.
PMID:12174
Abstract
A new ribonuclease called RNase N was isolated from Escherichia coli. It is a nonspecific endoribonuclease that can cleave rRNA, poly(U), and poly(C) to small oligonucleotides and 5'-mononucleotides. It requires monovalent cations and is inhibited by divalent cations. It is suggested that this enzyme plays a role in the decay of rRNA,under various starvation conditions and perhaps in the decay of mRNA.
摘要
一种名为核糖核酸酶N（RNase N）的新型核糖核酸酶从大肠杆菌中分离出来。它是一种非特异性内切核糖核酸酶，能够将核糖体RNA（rRNA）、聚尿苷酸（poly(U)）和聚胞苷酸（poly(C)）切割成小的寡核苷酸和5'-单核苷酸。它需要单价阳离子，并且会被二价阳离子抑制。有人认为这种酶在各种饥饿条件下rRNA的降解过程中发挥作用，也许还参与信使RNA（mRNA）的降解。
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