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[软骨母细胞瘤的诊断性影像学检查与治疗]

[Diagnostic imaging and therapy of chondroblastoma].

作者信息

Nickel Jens, Meyer Dirk-Roelfs, Geufke Peter, Andresen Reimer

机构信息

Abteilung für Radiologie, Krankenhaus Güstrow.

出版信息

Rontgenpraxis. 2002;54(6):224-31.

Abstract

The chondroblastoma is a rare lytic osseous lesion, which is typically to be found in the epiphyses of the long tubular bones. We present a case report with the differential diagnostic imaging and the surgical therapy of a chondroblastoma of the proximal tibial epiphysis. A 16-year-old male presented in the traumatological accident and emergency centre with knee pain of unclear origin that had been increasing for several months. He had no memory of any acute trauma. For further clarification, a conventional radiograph in two planes, a thin-layer CT, a multiplanar MRI before and after Gd-DTPA, and a bone scan were performed. The conventional radiological diagnostics show a smoothly circumscribed, osteolytic, eccentric lesion with marginal sclerosis, which not exceeds the epiphyseal seam of the proximal tibia. The thin-layer CT reveals an eccentric osteolysis, with a typical, narrow sclerotic seam and central calcifications. In the high-resolution MRI, the T2-weighted sequences show a locally limited, epiphyseal, lobulated lesion with a heterogeneous, in part raised signal. A further signal increase can be seen in the T1-weighted sequences after administration of Gd-DTPA. Perifocally, there is an epiphyseal edema and discrete (intraarticular fluid collection) fluid in the inner knee. In the skeletal scintigraphy, there is a strong focal and diffuse increased activity from the proximal, lateral tibial epiphysis. After the diagnosis had been rendered, curettage of the defect was performed and then, after histological confirmation of the diagnosis, completing spongiosaplasty was conducted. Taking into account the localisation and the patient's age, a virtually certain diagnosis can already be rendered using conventional imaging. A supplementary MRI or CT can be helpful for final clarification, while 3-phase skeletal scintigraphy is superfluous. The therapy of choice is curettage and subsequent filling of the defect with autologous spongiosa.

摘要

软骨母细胞瘤是一种罕见的溶骨性骨病变,通常见于长管状骨的骨骺。我们报告一例胫骨近端骨骺软骨母细胞瘤的鉴别诊断影像学及手术治疗病例。一名16岁男性因膝关节疼痛数月且原因不明就诊于创伤急诊中心。他不记得有任何急性创伤史。为进一步明确诊断,进行了两个平面的传统X线片、薄层CT、钆喷酸葡胺(Gd-DTPA)前后的多平面MRI以及骨扫描。传统放射学诊断显示为边界光滑的溶骨性、偏心性病变,伴有边缘硬化,未超过胫骨近端的骨骺线。薄层CT显示偏心性骨质溶解,有典型的狭窄硬化边及中央钙化。在高分辨率MRI上,T2加权序列显示局部局限的骨骺分叶状病变,信号不均匀,部分信号增高。注射Gd-DTPA后T1加权序列可见进一步信号增强。病灶周围有骨骺水肿,膝关节内有少量(关节内积液)液体。骨闪烁显像显示胫骨近端外侧骨骺有强烈的局灶性和弥漫性放射性增高。诊断明确后,对缺损进行刮除,然后在组织学确诊后进行植骨术。考虑到病变部位及患者年龄,使用传统影像学检查几乎可以确诊。补充的MRI或CT有助于最终明确诊断,而三相骨闪烁显像则不必要。首选的治疗方法是刮除并随后用自体松质骨填充缺损。

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