Leroux-Robert J, Bataini J P, Poncet P, Mazabraud A
Ann Otolaryngol Chir Cervicofac. 1975 Jun;92(6):249-76.
Research was carried out into a group of 11 patients with tumours of the olfactory placode or aesthesioneuromas observed and treated by the authors (10 of them unpublished cases). The authors recall the histological characteristics which, theoretically, distinguish aesthesioneuroepithelioma from aesthesioneurocytoma and aesthesioneuroblastoma and the risk of mistaken interpretation due to confusion with other types of tumour. The following conclusions emerged from this research : 1) Aesthesioneuroma is indisputably a radiosensitive tumour as has been proved by the long-term cures obtained either by irradiation alone or by irradiation after incomplete surgery. 2) However it is exceptional for diagnosis to be made merely by intranasal biopsy. In all doubtful cases, surgical investigation is necessary. This requires a broad para-latero nasal approach route which is the only one affording accurate anatomical localisation of the lesions and complete ablation of the tumour including, where necessary, removal of the lamina cribrosa.
对一组11例嗅基板肿瘤或嗅神经母细胞瘤患者进行了研究，这些患者由作者观察并治疗（其中10例为未发表病例）。作者回顾了组织学特征，从理论上讲，这些特征可将嗅神经上皮瘤与嗅神经细胞瘤和嗅神经母细胞瘤区分开来，以及因与其他类型肿瘤混淆而导致错误解读的风险。该研究得出以下结论：1）嗅神经母细胞瘤无疑是一种对放疗敏感的肿瘤，这已通过单独放疗或不完全手术后放疗获得的长期治愈得到证明。2）然而，仅通过鼻内活检进行诊断是例外情况。在所有可疑病例中，手术探查是必要的。这需要广泛的鼻旁外侧入路，这是唯一能够对病变进行准确解剖定位并完全切除肿瘤的方法，必要时包括切除筛板。
