Iskandar Samy S, Herrera Guillermo A
Department of Pathology, Wake Forest University School of Medicine, Winston-Salen, NC 27157-1072, USA.
Semin Diagn Pathol. 2002 Aug;19(3):116-32.
Glomerulopathies with organized deposits are much less frequent than those with usual-type immune complex deposits, even in busy renal biopsy practices. It is important to be able to provide the correct diagnosis because of the therapeutic and prognostic implications that may follow. This goal is achieved by thoughtful consideration of all pathologic and clinical findings. This review presents the salient features of amyloidosis, cryoglobulinemic glomerulonephritis, fibrillary glomerulonephritis, immunotactoid glomerulopathy, collagenofibrotic glomerulopathy, and fibronectin glomerulopathy. We also point out matrical fibrillary deposits that may mimic some of the above entities at the ultrastructural level. Emphasis is placed, through comparative illustrations, on the prominent role of electron microscopy.
即使在繁忙的肾活检实践中，伴有有组织沉积物的肾小球病也比伴有普通型免疫复合物沉积物的肾小球病少见得多。由于后续可能产生的治疗和预后影响，能够提供正确诊断很重要。通过对所有病理和临床发现进行深入思考来实现这一目标。本综述介绍了淀粉样变性、冷球蛋白血症性肾小球肾炎、纤维性肾小球肾炎、免疫触须样肾小球病、胶原纤维性肾小球病和纤维连接蛋白肾小球病的显著特征。我们还指出了在超微结构水平上可能模拟上述某些实体的基质纤维沉积物。通过对比插图，强调了电子显微镜的重要作用。
