氟烷在犬体内的摄取与消除：二室或多室系统？II：吸入和呼出曲线的评估

The uptake and elimination of halothane in dogs: A two or multicompartment system? II: Evaluation of wash-in and wash-out curves.

作者信息

Kolmer H H, Burm A G, Cramers C A, Ramakers J M, Vader H L

出版信息

Br J Anaesth. 1975 Nov;47(11):1169-75. doi: 10.1093/bja/47.11.1169.

DOI:10.1093/bja/47.11.1169

Abstract

In 14 mongrel dogs wash-in and wash-out curves for halothane were obtained from measurements of arterial blood, mixed venous blood and end-tidal gas. From a certain point in the wash-in period the halothane concentration of arterial blood can be calculated from the halothane concentration in end-tidal gas and the blood-gas partition coefficient for halothane. Analysis of the curves shows that they are composed of two exponential components suggesting the presence of two body compartments. The question of a two-compartment system versus a multi-compartment system in discussed.

摘要

在14只杂种狗身上，通过测量动脉血、混合静脉血和呼气末气体，获得了氟烷的吸入和呼出曲线。从吸入期的某一时刻起，可以根据呼气末气体中的氟烷浓度和氟烷的血气分配系数来计算动脉血中的氟烷浓度。对这些曲线的分析表明，它们由两个指数成分组成，提示存在两个身体房室。文中讨论了双房室系统与多房室系统的问题。