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[支气管哮喘患者中肺炎支原体抗原的抗体血清流行率]

[Antibodies seroprevalence for mycoplasma pneumoniae antigens in patients with bronchial asthma].

作者信息

Friedek Daniela, Ekiel Alicja, Szulakowski Patryk, Romanik Małgorzata

机构信息

Katedry i Zakładu Mikrobiologii, Slaskiej Akademii Medycznej w Katowicach.

出版信息

Wiad Lek. 2002;55(3-4):158-63.

Abstract

Microorganisms causing respiratory system infections, mainly viruses but also bacteria, among which there are atypical such as Chlamydophila pneumoniae, play a role in etiopathogenesis of bronchial asthma. Mycoplasma pneumoniae is suggested to take part in the initiation and the bronchial asthma exacerbation. The aim of the paper was to determine the frequency of occurrence of anti-Mycoplasma pneumoniae antibodies in serum of patients suffering from bronchial asthma in comparison with the control group of healthy persons. The presence of IgG, IgM and IgA class anti-Mycoplasma pneumoniae antibodies was assessed by immunoenzymatic assay ELISA. Serologic markers of Mycoplasma pneumoniae infection were more frequently observed in patients with bronchial asthma (15%) than in the control group (5.13%). The diagnosis of Mycoplasma pneumoniae infection is especially important in patients with bronchial asthma. The pathogen causing bronchial hyperreactivity is eliminated by the appropriate antibiotic therapy, which allows reducing the dose of inhaled corticosteroids. The immunoenzymatic assay determining the level and class of specific antibodies to find mycoplasmatic infection quickly and precisely.

摘要

引起呼吸系统感染的微生物,主要是病毒,但也有细菌,其中包括如肺炎衣原体等非典型微生物,它们在支气管哮喘的病因发病机制中起作用。肺炎支原体被认为参与支气管哮喘的起始和加重过程。本文的目的是确定支气管哮喘患者血清中抗肺炎支原体抗体的出现频率,并与健康对照组进行比较。通过免疫酶联测定法(ELISA)评估IgG、IgM和IgA类抗肺炎支原体抗体的存在情况。支气管哮喘患者(15%)比对照组(5.13%)更频繁地观察到肺炎支原体感染的血清学标志物。肺炎支原体感染的诊断在支气管哮喘患者中尤为重要。通过适当的抗生素治疗消除引起支气管高反应性的病原体,这可以减少吸入性皮质类固醇的剂量。免疫酶联测定法能快速、准确地测定特异性抗体的水平和类别以发现支原体感染。

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