Vorontsov V V
Biull Eksp Biol Med. 1975 Nov;80(11):53-7.
Diuretic and natriuretic action of chloracizine in rats was not associated with its direct influence on the kidney and was accompanied by increase in the plasma volume, by a fall of the hematocrite index and of the total plasma proteins. A study of endogenous creatinine and of osmotic-free water clearance showed the diuretic action of chloracizine to be mainly due to the increase of glomerular filtration and to reduction of the relative proximal reabsorption.
氯拉嗪对大鼠的利尿和排钠作用与其对肾脏的直接影响无关，且伴有血浆量增加、血细胞比容指数和血浆总蛋白下降。对内源性肌酐和无溶质水清除率的研究表明，氯拉嗪的利尿作用主要是由于肾小球滤过增加和近端肾小管相对重吸收减少。
