Setzer Matthias, Lang Josef, Turowski Bernd, Marquardt Gerhard
Department of Neurosurgery, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany.
Neurosurgery. 2002 Aug;51(2):488-92; discussion 492.
Primary meningeal osteosarcomas are extremely rare lesions; before this case report, only five cases had been reported in the literature. We encountered a patient with a meningeal osteosarcoma but no evidence of additional tumor at another remote site.
A 56-year-old man presented with progressive weakness of the right leg and the right arm. Computed tomography and magnetic resonance imaging revealed an extracerebral frontoparietal tumor on the left side.
The patient underwent complete resection of the tumor and subsequent radiotherapy of the tumor region. The histological examination showed evidence of the osteosarcoma, which was confined to the meninges. Postoperative adjuvant radiotherapy was administered. There was no tumor recurrence during 3 years of postoperative follow-up. Because the patient had no risk factors or further osteosarcomas, primary meningeal development was assumed.
Despite their rarity, osteosarcomas must be considered in the differential diagnosis of meningeal tumors.
原发性脑膜骨肉瘤是极其罕见的病变；在本病例报告之前，文献中仅报道过5例。我们遇到一名患有脑膜骨肉瘤的患者，但在其他远处部位未发现额外肿瘤的证据。
一名56岁男性出现右腿和右臂进行性无力。计算机断层扫描和磁共振成像显示左侧脑外额顶叶肿瘤。
患者接受了肿瘤的完整切除及随后肿瘤区域的放射治疗。组织学检查显示为骨肉瘤，局限于脑膜。术后给予辅助放疗。术后3年随访期间无肿瘤复发。由于患者无危险因素或进一步的骨肉瘤，推测为原发性脑膜起源。
尽管骨肉瘤罕见，但在脑膜肿瘤的鉴别诊断中必须考虑到。
