Singh Amit, Kango-Singh Madhuri, Sun Y Henry
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, 11529 Taiwan, Republic of China.
Development. 2002 Sep;129(18):4271-80. doi: 10.1242/dev.129.18.4271.
teashirt (tsh) encodes a Drosophila zinc-finger protein. Misexpression of tsh has been shown to induce ectopic eye formation in the antenna. We report that tsh can suppress eye development. This novel function of tsh is due to the induction of homothorax (hth), a known repressor of eye development, and requires Wingless (WG) signaling. Interestingly, tsh has different functions in the dorsal and ventral eye, suppressing eye development close to the ventral margin, while promoting eye development near the dorsal margin. It affects both growth of eye disc and retinal cell differentiation.
茶衫（tsh）编码一种果蝇锌指蛋白。已表明tsh的错误表达会在触角中诱导异位眼的形成。我们报告tsh可以抑制眼发育。tsh的这种新功能是由于同源胸节（hth）的诱导，hth是一种已知的眼发育抑制因子，并且需要无翅（WG）信号传导。有趣的是，tsh在背侧眼和腹侧眼中具有不同的功能，在靠近腹侧边缘处抑制眼发育，而在靠近背侧边缘处促进眼发育。它影响眼盘的生长和视网膜细胞的分化。
