犬恶丝虫多聚蛋白上调一氧化氮的产生。
A Dirofilaria immitis polyprotein up-regulates nitric oxide production.
作者信息
Tezuka Hiroyuki, Imai Shinjiro, Tsukidate Setsuko, Fujita Koichiro
机构信息
Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.
出版信息
Infect Immun. 2002 Sep;70(9):5283-6. doi: 10.1128/IAI.70.9.5283-5286.2002.
Abstract
We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40(-/-), mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.
摘要
我们研究了重组犬恶丝虫多聚蛋白（rDiAg）对腹膜巨噬细胞产生一氧化氮（NO）的影响。rDiAg可诱导野生型和对脂多糖反应低下的C3H/HeJ小鼠的巨噬细胞产生NO，但不能诱导CD40基因敲除小鼠的巨噬细胞产生NO。这些结果表明，CD40参与了rDiAg驱动的小鼠巨噬细胞产生NO的过程。
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